6Y3B
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2110
Summary for 6Y3B
Entry DOI | 10.2210/pdb6y3b/pdb |
Descriptor | Genome polyprotein, GLYCEROL, 1-[(8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, ... (6 entities in total) |
Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus |
Biological source | Zika virus More |
Total number of polymer chains | 2 |
Total formula weight | 25721.92 |
Authors | Huber, S.,Heine, A.,Steinmetzer, T. (deposition date: 2020-02-18, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Braun, N.J.,Quek, J.P.,Huber, S.,Kouretova, J.,Rogge, D.,Lang-Henkel, H.,Cheong, E.Z.K.,Chew, B.L.A.,Heine, A.,Luo, D.,Steinmetzer, T. Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses. Chemmedchem, 15:1439-1452, 2020 Cited by PubMed: 32501637DOI: 10.1002/cmdc.202000237 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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