6Y3B
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2110
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | ALA88 |
| B | TRP89 |
| B | ILE123 |
| B | GLY124 |
| B | ILE147 |
| B | ILE165 |
| B | HOH366 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | binding site for residue O7N B 202 |
| Chain | Residue |
| A | PHE84 |
| A | SER85 |
| B | HIS51 |
| B | TYR68 |
| B | GLY70 |
| B | ASP71 |
| B | VAL72 |
| B | ASP129 |
| B | TYR130 |
| B | ALA132 |
| B | SER135 |
| B | GLY151 |
| B | ASN152 |
| B | GLY153 |
| B | VAL155 |
| B | GLY159 |
| B | TYR161 |
| B | VAL176 |
| B | HOH319 |
| B | HOH322 |
| B | HOH330 |
| B | HOH332 |
| B | HOH348 |
| B | HOH353 |
| B | HOH354 |
| B | HOH367 |
| B | HOH370 |
| A | GLY82 |
| A | ASP83 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| A | LEU74 |
| B | ARG64 |
| B | ILE156 |
| B | LYS157 |
| B | HOH378 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"29080786","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29526431","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
