6XA2
Structure of the tirandamycin C-bound P450 monooxygenase TamI
Summary for 6XA2
Entry DOI | 10.2210/pdb6xa2/pdb |
Descriptor | TamI, PROTOPORPHYRIN IX CONTAINING FE, (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, ... (4 entities in total) |
Functional Keywords | p450, monooxygenase, oxidoreductase |
Biological source | Streptomyces sp. 307-9 |
Total number of polymer chains | 8 |
Total formula weight | 373712.21 |
Authors | Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H. (deposition date: 2020-06-03, release date: 2021-06-09, Last modification date: 2024-04-03) |
Primary citation | Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H. Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway. Acs Catalysis, 10:13445-13454, 2020 Cited by PubMed: 33569241DOI: 10.1021/acscatal.0c03248 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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