6XA2
Structure of the tirandamycin C-bound P450 monooxygenase TamI
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
B | 0020037 | molecular_function | heme binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0004497 | molecular_function | monooxygenase activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
C | 0020037 | molecular_function | heme binding |
C | 0046872 | molecular_function | metal ion binding |
D | 0004497 | molecular_function | monooxygenase activity |
D | 0005506 | molecular_function | iron ion binding |
D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
D | 0020037 | molecular_function | heme binding |
D | 0046872 | molecular_function | metal ion binding |
E | 0004497 | molecular_function | monooxygenase activity |
E | 0005506 | molecular_function | iron ion binding |
E | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
E | 0020037 | molecular_function | heme binding |
E | 0046872 | molecular_function | metal ion binding |
F | 0004497 | molecular_function | monooxygenase activity |
F | 0005506 | molecular_function | iron ion binding |
F | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
F | 0020037 | molecular_function | heme binding |
F | 0046872 | molecular_function | metal ion binding |
G | 0004497 | molecular_function | monooxygenase activity |
G | 0005506 | molecular_function | iron ion binding |
G | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
G | 0020037 | molecular_function | heme binding |
G | 0046872 | molecular_function | metal ion binding |
H | 0004497 | molecular_function | monooxygenase activity |
H | 0005506 | molecular_function | iron ion binding |
H | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
H | 0020037 | molecular_function | heme binding |
H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | MET100 |
A | THR256 |
A | LEU295 |
A | ALA298 |
A | THR299 |
A | ARG301 |
A | LEU324 |
A | ALA351 |
A | PHE352 |
A | GLY353 |
A | ILE356 |
A | LEU101 |
A | HIS357 |
A | CYS359 |
A | GLY361 |
A | ALA365 |
A | HIS108 |
A | ARG112 |
A | ILE163 |
A | LEU244 |
A | GLY248 |
A | GLY249 |
A | THR252 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue V0A A 502 |
Chain | Residue |
A | PHE92 |
A | LEU101 |
A | VAL185 |
A | GLY248 |
A | GLU251 |
A | THR252 |
A | LEU295 |
A | THR299 |
A | SER397 |
A | THR398 |
A | LEU399 |
A | ILE400 |
site_id | AC3 |
Number of Residues | 22 |
Details | binding site for residue HEM B 501 |
Chain | Residue |
B | MET100 |
B | LEU101 |
B | HIS108 |
B | ARG112 |
B | ILE163 |
B | LEU244 |
B | GLY249 |
B | THR252 |
B | THR256 |
B | ALA298 |
B | THR299 |
B | ARG301 |
B | LEU324 |
B | ALA351 |
B | PHE352 |
B | GLY353 |
B | ILE356 |
B | HIS357 |
B | CYS359 |
B | GLY361 |
B | LEU364 |
B | ALA365 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue V0A B 502 |
Chain | Residue |
B | VAL42 |
B | PRO43 |
B | VAL44 |
B | ALA91 |
B | PHE92 |
B | LEU101 |
B | LEU184 |
B | VAL185 |
B | GLY248 |
B | THR252 |
B | THR299 |
B | SER397 |
B | THR398 |
B | LEU399 |
B | ILE400 |
site_id | AC5 |
Number of Residues | 23 |
Details | binding site for residue HEM C 501 |
Chain | Residue |
C | MET100 |
C | LEU101 |
C | HIS108 |
C | ARG112 |
C | PHE119 |
C | ILE163 |
C | LEU244 |
C | GLY248 |
C | GLY249 |
C | THR252 |
C | THR256 |
C | LEU289 |
C | ALA298 |
C | THR299 |
C | ARG301 |
C | ALA351 |
C | PHE352 |
C | GLY353 |
C | ILE356 |
C | HIS357 |
C | CYS359 |
C | GLY361 |
C | ALA365 |
site_id | AC6 |
Number of Residues | 14 |
Details | binding site for residue V0A C 502 |
Chain | Residue |
C | VAL185 |
C | GLY248 |
C | GLU251 |
C | THR252 |
C | LEU295 |
C | THR299 |
C | SER397 |
C | THR398 |
C | LEU399 |
C | ILE400 |
C | ALA91 |
C | PHE92 |
C | LEU101 |
C | LEU184 |
site_id | AC7 |
Number of Residues | 24 |
Details | binding site for residue HEM D 501 |
Chain | Residue |
D | MET100 |
D | LEU101 |
D | HIS108 |
D | ARG112 |
D | PHE119 |
D | ILE163 |
D | LEU244 |
D | GLY249 |
D | THR252 |
D | THR256 |
D | LEU295 |
D | ALA298 |
D | THR299 |
D | ARG301 |
D | LEU324 |
D | ALA351 |
D | PHE352 |
D | GLY353 |
D | ILE356 |
D | HIS357 |
D | CYS359 |
D | GLY361 |
D | ALA365 |
D | V0A502 |
site_id | AC8 |
Number of Residues | 15 |
Details | binding site for residue V0A D 502 |
Chain | Residue |
D | ALA91 |
D | PHE92 |
D | LEU101 |
D | LEU184 |
D | VAL185 |
D | ILE247 |
D | GLY248 |
D | GLU251 |
D | THR252 |
D | THR299 |
D | SER397 |
D | THR398 |
D | LEU399 |
D | ILE400 |
D | HEM501 |
site_id | AC9 |
Number of Residues | 23 |
Details | binding site for residue HEM E 501 |
Chain | Residue |
E | MET100 |
E | LEU101 |
E | HIS108 |
E | ARG112 |
E | PHE119 |
E | ILE163 |
E | LEU244 |
E | GLY248 |
E | GLY249 |
E | THR252 |
E | THR256 |
E | LEU295 |
E | ALA298 |
E | THR299 |
E | ARG301 |
E | ALA351 |
E | PHE352 |
E | GLY353 |
E | ILE356 |
E | HIS357 |
E | CYS359 |
E | GLY361 |
E | ALA365 |
site_id | AD1 |
Number of Residues | 13 |
Details | binding site for residue V0A E 502 |
Chain | Residue |
E | ALA91 |
E | PHE92 |
E | LEU101 |
E | LEU184 |
E | VAL185 |
E | GLY248 |
E | THR252 |
E | LEU295 |
E | THR299 |
E | SER397 |
E | THR398 |
E | LEU399 |
E | ILE400 |
site_id | AD2 |
Number of Residues | 23 |
Details | binding site for residue HEM F 501 |
Chain | Residue |
F | MET100 |
F | LEU101 |
F | HIS108 |
F | ARG112 |
F | PHE119 |
F | LEU244 |
F | GLY249 |
F | THR252 |
F | THR256 |
F | LEU295 |
F | ALA298 |
F | THR299 |
F | ARG301 |
F | ALA351 |
F | PHE352 |
F | GLY353 |
F | ILE356 |
F | HIS357 |
F | CYS359 |
F | GLY361 |
F | LEU364 |
F | ALA365 |
F | V0A502 |
site_id | AD3 |
Number of Residues | 15 |
Details | binding site for residue V0A F 502 |
Chain | Residue |
F | VAL44 |
F | ALA91 |
F | PHE92 |
F | LEU101 |
F | LEU184 |
F | VAL185 |
F | GLY248 |
F | THR252 |
F | LEU295 |
F | THR299 |
F | SER397 |
F | THR398 |
F | LEU399 |
F | ILE400 |
F | HEM501 |
site_id | AD4 |
Number of Residues | 25 |
Details | binding site for residue HEM G 501 |
Chain | Residue |
G | MET100 |
G | LEU101 |
G | HIS108 |
G | ARG112 |
G | ILE163 |
G | LEU244 |
G | GLY248 |
G | GLY249 |
G | THR252 |
G | THR256 |
G | LEU295 |
G | ALA298 |
G | THR299 |
G | ARG301 |
G | LEU324 |
G | ALA351 |
G | PHE352 |
G | GLY353 |
G | ILE356 |
G | HIS357 |
G | CYS359 |
G | GLY361 |
G | LEU364 |
G | ALA365 |
G | V0A502 |
site_id | AD5 |
Number of Residues | 15 |
Details | binding site for residue V0A G 502 |
Chain | Residue |
G | VAL44 |
G | ALA91 |
G | PHE92 |
G | LEU101 |
G | LEU184 |
G | VAL185 |
G | ILE247 |
G | THR252 |
G | LEU295 |
G | THR299 |
G | SER397 |
G | THR398 |
G | LEU399 |
G | ILE400 |
G | HEM501 |
site_id | AD6 |
Number of Residues | 21 |
Details | binding site for residue HEM H 501 |
Chain | Residue |
H | MET100 |
H | LEU101 |
H | HIS108 |
H | ARG112 |
H | LEU245 |
H | GLY248 |
H | GLY249 |
H | THR252 |
H | THR256 |
H | LEU289 |
H | ALA298 |
H | THR299 |
H | ARG301 |
H | ALA351 |
H | PHE352 |
H | GLY353 |
H | ILE356 |
H | HIS357 |
H | CYS359 |
H | GLY361 |
H | ALA365 |
site_id | AD7 |
Number of Residues | 11 |
Details | binding site for residue V0A H 502 |
Chain | Residue |
H | PHE92 |
H | LEU101 |
H | VAL185 |
H | GLY248 |
H | THR252 |
H | LEU295 |
H | THR299 |
H | SER397 |
H | THR398 |
H | LEU399 |
H | ILE400 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGIHYCLG |
Chain | Residue | Details |
A | PHE352-GLY361 |