6X7C
BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212
Summary for 6X7C
Entry DOI | 10.2210/pdb6x7c/pdb |
Descriptor | Bromodomain-containing protein 4, 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide (3 entities in total) |
Functional Keywords | brd4, pi3k, cdk4/6, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16359.79 |
Authors | Vann, K.R.,Kutateladze, T.G. (deposition date: 2020-05-29, release date: 2020-08-05, Last modification date: 2023-10-18) |
Primary citation | Vann, K.R.,Pal, D.,Morales, G.A.,Burgoyne, A.M.,Durden, D.L.,Kutateladze, T.G. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10:12027-12027, 2020 Cited by PubMed: 32694708DOI: 10.1038/s41598-020-68964-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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