6X3O
Co-structure of BTK kinase domain with L-005191930 inhibitor
Summary for 6X3O
Entry DOI | 10.2210/pdb6x3o/pdb |
Descriptor | Tyrosine-protein kinase BTK, 4-{8-amino-3-[(6R,8aS)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, ... (4 entities in total) |
Functional Keywords | bruton tyrosine kinase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65364.93 |
Authors | Fischmann, T.O. (deposition date: 2020-05-21, release date: 2020-07-22, Last modification date: 2024-03-06) |
Primary citation | Liu, J.,Guiadeen, D.,Krikorian, A.,Gao, X.,Wang, J.,Babu Boga, S.,Alhassan, A.B.,Yu, W.,Selyutin, O.,Yu, Y.,Anand, R.,Xu, J.,Kelly, J.,Duffy, J.L.,Liu, S.,Yang, C.,Wu, H.,Cai, J.,Bennett, C.,Maloney, K.M.,Tyagarajan, S.,Gao, Y.D.,Fischmann, T.O.,Presland, J.,Mansueto, M.,Xu, Z.,Leccese, E.,Zhang-Hoover, J.,Knemeyer, I.,Garlisi, C.G.,Stivers, P.,Brandish, P.E.,Hicks, A.,Kim, R.,Kozlowski, J.A. Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes. Bioorg.Med.Chem.Lett., 30:127390-127390, 2020 Cited by PubMed: 32738973DOI: 10.1016/j.bmcl.2020.127390 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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