6X3O
Co-structure of BTK kinase domain with L-005191930 inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase BTK | polymer | 271 | 31598.3 | 2 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase |
2 | A, B | 4-{8-amino-3-[(6R,8aS)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | non-polymer | 565.5 | 2 | Chemie (ULY) | |||
3 | A, B | 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide | non-polymer | 518.6 | 2 | Chemie (5WE) | |||
4 | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 63196.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2168.4 | |
All* | Total formula weight | 65364.9 |