6WOK
Crystal structure of estrogen receptor alpha in complex with receptor degrader 6
Summary for 6WOK
Entry DOI | 10.2210/pdb6wok/pdb |
Descriptor | Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, ... (4 entities in total) |
Functional Keywords | era, antagonist, inverse agonist, receptor, breast cancer, degrader, ligand, estrogen receptor, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 130800.72 |
Authors | Kiefer, J.R.,Vinogradova, M.,Liang, J.,Zhang, B.,Wang, X.,Labadie, S. (deposition date: 2020-04-24, release date: 2020-07-01, Last modification date: 2023-11-01) |
Primary citation | Liang, J.,Blake, R.,Chang, J.,Friedman, L.S.,Goodacre, S.,Hartman, S.,Ingalla, E.R.,Kiefer, J.R.,Kleinheinz, T.,Labadie, S.,Li, J.,Lai, K.W.,Liao, J.,Mody, V.,McLean, N.,Metcalfe, C.,Nannini, M.,Otwine, D.,Ran, Y.,Ray, N.,Roussel, F.,Sambrone, A.,Sampath, D.,Vinogradova, M.,Wai, J.,Wang, T.,Yeap, K.,Young, A.,Zbieg, J.,Zhang, B.,Zheng, X.,Zhong, Y.,Wang, X. Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. Acs Med.Chem.Lett., 11:1342-1347, 2020 Cited by PubMed: 32551022DOI: 10.1021/acsmedchemlett.0c00224 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.309 Å) |
Structure validation
Download full validation report