6WOK
Crystal structure of estrogen receptor alpha in complex with receptor degrader 6
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue G9J D 601 |
| Chain | Residue |
| D | LEU346 |
| D | GLY521 |
| D | HIS524 |
| D | LEU525 |
| D | HOH702 |
| D | ALA350 |
| D | GLU353 |
| D | LEU387 |
| D | MET388 |
| D | ARG394 |
| D | PHE404 |
| D | MET421 |
| D | ILE424 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue U6D A 601 |
| Chain | Residue |
| A | MET343 |
| A | LEU346 |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU354 |
| A | LEU384 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | ILE424 |
| A | GLY521 |
| A | LEU525 |
| A | VAL533 |
| A | PRO535 |
| A | LEU539 |
| A | G9J602 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue G9J A 602 |
| Chain | Residue |
| A | LEU346 |
| A | THR347 |
| A | ALA350 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | ILE424 |
| A | GLY521 |
| A | VAL533 |
| A | U6D601 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue U6D C 601 |
| Chain | Residue |
| C | MET343 |
| C | LEU346 |
| C | THR347 |
| C | ASP351 |
| C | GLU353 |
| C | TRP383 |
| C | LEU384 |
| C | ARG394 |
| C | MET421 |
| C | ILE424 |
| C | GLY521 |
| C | HIS524 |
| C | LEU525 |
| C | VAL534 |
| C | PRO535 |
| C | G9J602 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue G9J C 602 |
| Chain | Residue |
| C | LEU346 |
| C | THR347 |
| C | ALA350 |
| C | GLU353 |
| C | LEU387 |
| C | ARG394 |
| C | MET421 |
| C | ILE424 |
| C | U6D601 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue U6D B 601 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | LEU354 |
| B | LEU387 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | ILE424 |
| B | GLY521 |
| B | LEU525 |
| B | VAL534 |
| B | PRO535 |
| B | LEU539 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
