6WJ2

CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state

Summary for 6WJ2

• Entry DOI: 10.2210/pdb6wj2/pdb
• Related: 6WJ3
• EMDB information: 21686 21687
• Descriptor: Ragulator complex protein LAMTOR1, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, MAGNESIUM ION, ... (11 entities in total)
• Functional Keywords: small gtpase, mtorc1 activation, amino acid signaling, lysosome, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 173278.65

Authors

Fromm, S.A.,Hurley, J.H. (deposition date: 2020-04-11, release date: 2020-09-02, Last modification date: 2024-03-06)

• Primary citation: Fromm, S.A.,Lawrence, R.E.,Hurley, J.H.; Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.; Nat.Struct.Mol.Biol., 27:1017-1023, 2020; PubMed: 32868926; DOI: 10.1038/s41594-020-0490-9

Experimental method

ELECTRON MICROSCOPY (3.2 Å)