6WJ2
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ragulator complex protein LAMTOR1 | polymer | 166 | 18325.3 | 1 | UniProt (Q6IAA8) Pfam (PF15454) In PDB | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
2 | B | Ragulator complex protein LAMTOR2 | polymer | 127 | 13645.6 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) In PDB | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
3 | C | Ragulator complex protein LAMTOR3 | polymer | 124 | 13637.7 | 1 | UniProt (Q9UHA4) Pfam (PF08923) In PDB | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
4 | D | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 1 | UniProt (Q0VGL1) In PDB | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
5 | E | Ragulator complex protein LAMTOR5 | polymer | 173 | 18178.5 | 1 | UniProt (A0A0C4DGV4) Pfam (PF16672) UniProt (by SIFTS) (O43504) In PDB | Homo sapiens (Human) | Hepatitis B virus x interacting protein |
6 | F | Ras-related GTP-binding protein A | polymer | 336 | 39362.1 | 1 | UniProt (Q7L523) Pfam (PF04670) In PDB | Homo sapiens (Human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
7 | G | Ras-related GTP-binding protein C | polymer | 404 | 44758.3 | 1 | UniProt (Q9HB90) Pfam (PF04670) In PDB | Homo sapiens (Human) | RagC,GTPase-interacting protein 2,TIB929 |
8 | H | Sodium-coupled neutral amino acid transporter 9 | polymer | 122 | 13610.1 | 1 | UniProt (Q8NBW4) In PDB | Homo sapiens (Human) | Solute carrier family 38 member 9,Up-regulated in lung cancer 11 |
9 | F | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
10 | G | 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione | non-polymer | 540.2 | 1 | Chemie (L8S) | |||
11 | G | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 161 (UniProt: Q6IAA8)
B: 1 - 125 (UniProt: Q9Y2Q5)
F: 1 - 313 (UniProt: Q7L523)
G: 1 - 399 (UniProt: Q9HB90)
H: 1 - 119 (UniProt: Q8NBW4)
PDB | External Database | Details |
---|---|---|
Ser -4 | - | expression tag |
Asn -3 | - | expression tag |
Ala -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Ala 2 | Gly 2 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -22 | - | expression tag |
Ser -21 | - | expression tag |
Trp -20 | - | expression tag |
Ser -19 | - | expression tag |
His -18 | - | expression tag |
Pro -17 | - | expression tag |
Gln -16 | - | expression tag |
Phe -15 | - | expression tag |
Glu -14 | - | expression tag |
Lys -13 | - | expression tag |
Gly -12 | - | expression tag |
Gly -11 | - | expression tag |
Phe -10 | - | expression tag |
Asp -9 | - | expression tag |
Ile -8 | - | expression tag |
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Ala -3 | - | expression tag |
Asp -2 | - | expression tag |
Ser -1 | - | expression tag |
Arg 0 | - | expression tag |
Asn 181 | Asp 181 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 172270.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1007.7 | |
All* | Total formula weight | 173278.7 |