6W4Y
Structure of full-length human lambda-6A light chain JTO in complex with hydantoin stabilizer
Summary for 6W4Y
Entry DOI | 10.2210/pdb6w4y/pdb |
Descriptor | JTO light chain, 2-[(4~{R})-4-(2-methylpropyl)-2,5-bis(oxidanylidene)imidazolidin-1-yl]-~{N}-[4-(trifluoromethyl)phenyl]ethanamide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | amyloidosis, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47062.45 |
Authors | Yan, N.L.,Morgan, G.J.,Kelly, J.W. (deposition date: 2020-03-11, release date: 2020-07-01, Last modification date: 2023-10-18) |
Primary citation | Yan, N.L.,Santos-Martins, D.,Rennella, E.,Sanchez, B.B.,Chen, J.S.,Kay, L.E.,Wilson, I.A.,Morgan, G.J.,Forli, S.,Kelly, J.W. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorg.Med.Chem.Lett., 30:127356-127356, 2020 Cited by PubMed: 32631553DOI: 10.1016/j.bmcl.2020.127356 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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