6W4Y

Structure of full-length human lambda-6A light chain JTO in complex with hydantoin stabilizer

Summary for 6W4Y

• Entry DOI: 10.2210/pdb6w4y/pdb
• Descriptor: JTO light chain, 2-[(4~{R})-4-(2-methylpropyl)-2,5-bis(oxidanylidene)imidazolidin-1-yl]-~{N}-[4-(trifluoromethyl)phenyl]ethanamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: amyloidosis, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47062.45

Authors

Yan, N.L.,Morgan, G.J.,Kelly, J.W. (deposition date: 2020-03-11, release date: 2020-07-01, Last modification date: 2023-10-18)

• Primary citation: Yan, N.L.,Santos-Martins, D.,Rennella, E.,Sanchez, B.B.,Chen, J.S.,Kay, L.E.,Wilson, I.A.,Morgan, G.J.,Forli, S.,Kelly, J.W.; Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.; Bioorg.Med.Chem.Lett., 30:127356-127356, 2020; PubMed: 32631553; DOI: 10.1016/j.bmcl.2020.127356

Experimental method

X-RAY DIFFRACTION (1.91 Å)