6VXJ
Structure of ABCG2 bound to SN38
Summary for 6VXJ
Entry DOI | 10.2210/pdb6vxj/pdb |
EMDB information | 21436 21437 21438 21439 21440 21441 |
Descriptor | Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, 7-ethyl-10-hydroxycamptothecin (3 entities in total) |
Functional Keywords | abcg2, sn38, abc transporter, nanodisc, translocase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 145937.42 |
Authors | Orlando, B.J.,Liao, M. (deposition date: 2020-02-22, release date: 2020-05-13, Last modification date: 2024-10-09) |
Primary citation | Orlando, B.J.,Liao, M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11:2264-2264, 2020 Cited by PubMed: 32385283DOI: 10.1038/s41467-020-16155-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
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