6VSZ
Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Summary for 6VSZ
Entry DOI | 10.2210/pdb6vsz/pdb |
Descriptor | Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | immune system, immunoglobulin, crystallizable fragment, igg1, fc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 50794.78 |
Authors | Tolbert, W.D.,Pazgier, M. (deposition date: 2020-02-12, release date: 2021-02-17, Last modification date: 2023-10-11) |
Primary citation | Anand, S.P.,Ding, S.,Tolbert, W.D.,Prevost, J.,Richard, J.,Gil, H.M.,Gendron-Lepage, G.,Cheung, W.F.,Wang, H.,Pastora, R.,Saxena, H.,Wakarchuk, W.,Medjahed, H.,Wines, B.D.,Hogarth, M.,Shaw, G.M.,Martin, M.A.,Burton, D.R.,Hangartner, L.,Evans, D.T.,Pazgier, M.,Cossar, D.,McLean, M.D.,Finzi, A. Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells. J.Virol., 95:e0079621-e0079621, 2021 Cited by PubMed: 34232070DOI: 10.1128/JVI.00796-21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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