6VPJ
TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + C319V double mutant dephosphorylated, and in complex with AMP-PNP
Summary for 6VPJ
Entry DOI | 10.2210/pdb6vpj/pdb |
Related PRD ID | PRD_900006 |
Descriptor | TPX2 fragment - Aurora A kinase domain fusion, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | ser/thr kinase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 34747.22 |
Authors | Lim, D.C.,Yaffe, M.B. (deposition date: 2020-02-03, release date: 2020-08-05, Last modification date: 2024-04-03) |
Primary citation | Lim, D.C.,Joukov, V.,Rettenmaier, T.J.,Kumagai, A.,Dunphy, W.G.,Wells, J.A.,Yaffe, M.B. Redox priming promotes Aurora A activation during mitosis. Sci.Signal., 13:-, 2020 Cited by PubMed: 32694171DOI: 10.1126/scisignal.abb6707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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