6VA4

Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP

Summary for 6VA4

• Entry DOI: 10.2210/pdb6va4/pdb
• NMR Information: BMRB: 30700
• Descriptor: RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3'), RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), N-[3-(8-methoxy-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propyl]-N-methylcyclohexanaminium (3 entities in total)
• Functional Keywords: adenine bulge, rna complex, a-form tau rna hairpin, rna, mip
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 7083.60

Authors

Chen, J.L.,Fountain, M.A.,Disney, M.D. (deposition date: 2019-12-16, release date: 2020-05-20, Last modification date: 2022-03-16)

• Primary citation: Chen, J.L.,Zhang, P.,Abe, M.,Aikawa, H.,Zhang, L.,Frank, A.J.,Zembryski, T.,Hubbs, C.,Park, H.,Withka, J.,Steppan, C.,Rogers, L.,Cabral, S.,Pettersson, M.,Wager, T.T.,Fountain, M.A.,Rumbaugh, G.,Childs-Disney, J.L.,Disney, M.D.; Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.; J.Am.Chem.Soc., 142:8706-8727, 2020; PubMed: 32364710; DOI: 10.1021/jacs.0c00768

Experimental method

SOLUTION NMR