6V7A
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2657
Summary for 6V7A
Entry DOI | 10.2210/pdb6v7a/pdb |
Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | histone deacetylase, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 40780.53 |
Authors | Osko, J.D.,Christianson, D.W. (deposition date: 2019-12-08, release date: 2020-12-02, Last modification date: 2023-10-11) |
Primary citation | Saraswati, A.P.,Relitti, N.,Brindisi, M.,Osko, J.D.,Chemi, G.,Federico, S.,Grillo, A.,Brogi, S.,McCabe, N.H.,Turkington, R.C.,Ibrahim, O.,O'Sullivan, J.,Lamponi, S.,Ghanim, M.,Kelly, V.P.,Zisterer, D.,Amet, R.,Hannon Barroeta, P.,Vanni, F.,Ulivieri, C.,Herp, D.,Sarno, F.,Di Costanzo, A.,Saccoccia, F.,Ruberti, G.,Jung, M.,Altucci, L.,Gemma, S.,Butini, S.,Christianson, D.W.,Campiani, G. Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. Acs Med.Chem.Lett., 11:2268-2276, 2020 Cited by PubMed: 33214839DOI: 10.1021/acsmedchemlett.0c00395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08741757573 Å) |
Structure validation
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