6UKM
STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound MSA-2
Summary for 6UKM
Entry DOI | 10.2210/pdb6ukm/pdb |
Descriptor | fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain, 4-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid (3 entities in total) |
Functional Keywords | agonist, sting (stimulator of interferon genes), transmembrane protein 173 (tmem173), immune system, immune system-inhibitor complex, immune system-agonist complex |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More |
Total number of polymer chains | 1 |
Total formula weight | 34750.85 |
Authors | Lesburg, C.A. (deposition date: 2019-10-05, release date: 2020-08-19, Last modification date: 2023-10-11) |
Primary citation | Pan, B.S.,Perera, S.A.,Piesvaux, J.A.,Presland, J.P.,Schroeder, G.K.,Cumming, J.N.,Trotter, B.W.,Altman, M.D.,Buevich, A.V.,Cash, B.,Cemerski, S.,Chang, W.,Chen, Y.,Dandliker, P.J.,Feng, G.,Haidle, A.,Henderson, T.,Jewell, J.,Kariv, I.,Knemeyer, I.,Kopinja, J.,Lacey, B.M.,Laskey, J.,Lesburg, C.A.,Liang, R.,Long, B.J.,Lu, M.,Ma, Y.,Minnihan, E.C.,O'Donnell, G.,Otte, R.,Price, L.,Rakhilina, L.,Sauvagnat, B.,Sharma, S.,Tyagarajan, S.,Woo, H.,Wyss, D.F.,Xu, S.,Bennett, D.J.,Addona, G.H. An orally available non-nucleotide STING agonist with antitumor activity. Science, 369:-, 2020 Cited by PubMed: 32820094DOI: 10.1126/science.aba6098 PDB entries with the same primary citation |
Experimental method |
Structure validation
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