6UKM
STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound MSA-2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000794 | cellular_component | condensed nuclear chromosome |
A | 0002218 | biological_process | activation of innate immune response |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005940 | cellular_component | septin ring |
A | 0016925 | biological_process | protein sumoylation |
A | 0031386 | molecular_function | protein tag activity |
A | 0032481 | biological_process | positive regulation of type I interferon production |
A | 0042802 | molecular_function | identical protein binding |
A | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue QAD A 401 |
Chain | Residue |
A | LEU159 |
A | HOH504 |
A | HOH508 |
A | HOH554 |
A | SER162 |
A | TYR163 |
A | TYR167 |
A | ARG238 |
A | ARG238 |
A | THR263 |
A | THR263 |
A | PRO264 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950 |
Chain | Residue | Details |
A | SER51 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
Chain | Residue | Details |
A | SER53 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
A | GLY147 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
Chain | Residue | Details |
A | LYS338 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
Chain | Residue | Details |
A | SER162 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
Chain | Residue | Details |
A | TYR167 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
Chain | Residue | Details |
A | ARG238 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
Chain | Residue | Details |
A | THR263 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
Chain | Residue | Details |
A | THR229 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
Chain | Residue | Details |
A | SER241 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
Chain | Residue | Details |
A | LYS236 |