6UIW

Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state

Summary for 6UIW

• Entry DOI: 10.2210/pdb6uiw/pdb
• EMDB information: 20788 20789 20790
• Descriptor: Calcium homeostasis modulator protein 2, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (2 entities in total)
• Functional Keywords: calcium homeostasis modulator, calhm2, ruthenium red, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 11
• Total formula weight: 415340.21

Authors

Lu, W.,Du, J.,Choi, W. (deposition date: 2019-10-01, release date: 2019-11-27, Last modification date: 2019-12-18)

• Primary citation: Choi, W.,Clemente, N.,Sun, W.,Du, J.,Lu, W.; The structures and gating mechanism of human calcium homeostasis modulator 2.; Nature, 576:163-167, 2019; PubMed: 31776515; DOI: 10.1038/s41586-019-1781-3

Experimental method

ELECTRON MICROSCOPY (2.7 Å)