6UGU
Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a C-centered orthorhombic crystal form, Lot C
Summary for 6UGU
Entry DOI | 10.2210/pdb6ugu/pdb |
Descriptor | PF06438179 Fab Heavy Chain, PF06438179 Fab Light Chain (3 entities in total) |
Functional Keywords | antibody, fab, infliximab, biosimilar, tnfa, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 95634.10 |
Authors | Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Conlan, H.D. (deposition date: 2019-09-26, release date: 2019-11-13, Last modification date: 2023-10-11) |
Primary citation | Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Zou, Q.,Conlon, H.D. Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar. BioDrugs, 34:77-87, 2020 Cited by PubMed: 31650490DOI: 10.1007/s40259-019-00390-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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