6U9M
MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109)
Summary for 6U9M
Entry DOI | 10.2210/pdb6u9m/pdb |
Related | 6U9K |
Descriptor | Histone-lysine N-methyltransferase, ZINC ION, 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, ... (5 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37774.53 |
Authors | Petrunak, E.M.,Stuckey, J.A. (deposition date: 2019-09-09, release date: 2020-07-01, Last modification date: 2023-10-11) |
Primary citation | Chern, T.R.,Liu, L.,Petrunak, E.,Stuckey, J.A.,Wang, M.,Bernard, D.,Zhou, H.,Lee, S.,Dou, Y.,Wang, S. Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11:1348-1352, 2020 Cited by PubMed: 32551023DOI: 10.1021/acsmedchemlett.0c00229 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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