6U77

yGsy2p in complex with small molecule

Summary for 6U77

Entry DOI	10.2210/pdb6u77/pdb
Descriptor	Glycogen [starch] synthase isoform 2, 6-O-phosphono-alpha-D-glucopyranose, 2-methoxy-4-(1-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-4-phenyl-1H-imidazol-5-yl)phenol (3 entities in total)
Functional Keywords	inhibitor, glycogen synthase, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Total number of polymer chains	4
Total formula weight	323232.02
Authors	Tang, B.,Hurley, T.D. (deposition date: 2019-08-31, release date: 2020-03-18, Last modification date: 2023-10-11)
Primary citation	Tang, B.,Frasinyuk, M.S.,Chikwana, V.M.,Mahalingan, K.K.,Morgan, C.A.,Segvich, D.M.,Bondarenko, S.P.,Mrug, G.P.,Wyrebek, P.,Watt, D.S.,DePaoli-Roach, A.A.,Roach, P.J.,Hurley, T.D. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J.Med.Chem., 63:3538-3551, 2020 Cited by PubMed: 32134266 DOI: 10.1021/acs.jmedchem.9b01851 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation