6U65
Mcl-1 bound to compound 19
Summary for 6U65
Entry DOI | 10.2210/pdb6u65/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 2-[({4-[(4-fluorophenyl)methyl]piperazin-1-yl}sulfonyl)amino]-5-[(2-phenylethyl)sulfanyl]benzoic acid, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | anti-apoptotic, inhibitor, protein binding, apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 74307.32 |
Authors | Stuckey, J.A. (deposition date: 2019-08-29, release date: 2020-03-04, Last modification date: 2024-03-13) |
Primary citation | Kump, K.J.,Miao, L.,Mady, A.S.A.,Ansari, N.H.,Shrestha, U.K.,Yang, Y.,Pal, M.,Liao, C.,Perdih, A.,Abulwerdi, F.A.,Chinnaswamy, K.,Meagher, J.L.,Carlson, J.M.,Khanna, M.,Stuckey, J.A.,Nikolovska-Coleska, Z. Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J.Med.Chem., 63:2489-2510, 2020 Cited by PubMed: 31971799DOI: 10.1021/acs.jmedchem.9b01442 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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