6U65

Mcl-1 bound to compound 19

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue Q0A A 401

Chain	Residue
A	MET231
B	THR226
B	ALA227
B	GLY230
B	ARG233
B	Q0A401
B	HOH518
A	LEU235
A	MET250
A	VAL253
A	ARG263
A	THR266
A	LEU267
A	PHE270
A	LEU290

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 402

Chain	Residue
A	GLY311
A	HOH502

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 403

Chain	Residue
A	ASN260
A	TRP261
A	TRP305
A	GLN309
D	SER255

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 404

Chain	Residue
A	ASN282
A	GLN283
A	GLU284
A	SER285
B	ILE281
B	ASN282

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 405

Chain	Residue
A	ARG207
A	GLU211
A	ARG214

---

site_id	AC6
Number of Residues	13
Details	binding site for residue Q0A B 401

Chain	Residue
A	THR226
A	ALA227
A	GLY230
A	ARG233
A	Q0A401
B	MET231
B	LEU235
B	MET250
B	VAL253
B	ARG263
B	THR266
B	LEU267
B	LEU290

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT B 402

Chain	Residue
A	ASP304
B	THR259
B	THR301
B	LYS302
B	ASP304
B	TRP305

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT B 403

Chain	Residue
B	LEU232
B	ASP236
B	ILE237
B	HOH524

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO B 404

Chain	Residue
B	TYR185
B	GLU188
B	GLN189
B	ARG214
B	ASP218

---

site_id	AD1
Number of Residues	14
Details	binding site for residue Q0A C 401

Chain	Residue
C	MET231
C	LEU235
C	MET250
C	ARG263
C	THR266
C	LEU267
C	PHE270
C	LEU290
D	THR226
D	ALA227
D	GLY230
D	ARG233
D	Q0A401
D	HOH508

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ACT C 402

Chain	Residue
C	GLN229
C	PHE273
C	LYS276
C	HIS277

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO C 405

Chain	Residue
C	GLU173
C	ARG176
C	GLU180
C	GLY200
C	ARG201

---

site_id	AD4
Number of Residues	14
Details	binding site for residue Q0A D 401

Chain	Residue
C	THR226
C	ALA227
C	GLY230
C	MET231
C	Q0A401
D	MET231
D	ARG263
D	THR266
D	LEU267
D	PHE270
D	GLY271
D	VAL274
D	LEU290
D	EDO403

---

site_id	AD5
Number of Residues	6
Details	binding site for residue ACT D 402

Chain	Residue
A	GLU288
D	THR196
D	PRO198
A	ARG187
A	THR191
A	GLU284

---

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO D 403

Chain	Residue
C	THR226
C	GLN229
C	GLY230
D	VAL258
D	ASN260
D	ARG263
D	Q0A401

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA

Chain	Residue	Details
A	VAL253-ALA272

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV

Chain	Residue	Details
A	TRP305-VAL316

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN

Chain	Residue	Details
A	ALA209-ASN223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

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