6TQG
Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor
Summary for 6TQG
Entry DOI | 10.2210/pdb6tqg/pdb |
Descriptor | Glucose-1-phosphate thymidylyltransferase, ~{N}-[1-[(4-bromophenyl)methyl]-6-[3-(methylamino)propylamino]-2,4-bis(oxidanylidene)pyrimidin-5-yl]-~{N}-methyl-benzenesulfonamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | rmla, allostery, thymidylyltransferase, inhibitor, transferase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 4 |
Total formula weight | 137866.82 |
Authors | Alphey, M.S.,Xiao, G.,Westwood, J.N. (deposition date: 2019-12-16, release date: 2020-08-19, Last modification date: 2024-01-24) |
Primary citation | Xiao, G.,Alphey, M.S.,Tran, F.,Pirrie, L.,Milbeo, P.,Zhou, Y.,Bickel, J.K.,Kempf, O.,Kempf, K.,Naismith, J.H.,Westwood, N.J. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg.Med.Chem., 50:116477-116477, 2021 Cited by PubMed: 34757294DOI: 10.1016/j.bmc.2021.116477 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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