6TO2
Crystal structure of CYP154C5 from Nocardia farcinica in complex with 5alpha-Androstan-3-one
Summary for 6TO2
Entry DOI | 10.2210/pdb6to2/pdb |
Descriptor | Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (5~{S},8~{S},9~{S},10~{S},13~{S},14~{S})-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one, ... (5 entities in total) |
Functional Keywords | cytochrome p450, steroid hydroxylating monooxygenase, steroid binding, oxidoreductase-substrate complex, oxidoreductase |
Biological source | Nocardia farcinica IFM 10152 |
Total number of polymer chains | 2 |
Total formula weight | 92291.98 |
Authors | Rodriguez, A.,Kluenemann, T.,Blankenfeldt, W.,Schallmey, A. (deposition date: 2019-12-11, release date: 2020-11-18, Last modification date: 2024-01-24) |
Primary citation | Bracco, P.,Wijma, H.J.,Nicolai, B.,Buitrago, J.A.R.,Klunemann, T.,Vila, A.,Schrepfer, P.,Blankenfeldt, W.,Janssen, D.B.,Schallmey, A. CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering*. Chembiochem, 22:1099-1110, 2021 Cited by PubMed: 33145893DOI: 10.1002/cbic.202000735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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