Summary for 6TKR
Entry DOI | 10.2210/pdb6tkr/pdb |
Descriptor | Tankyrase-2, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-2-carboxamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, poly-adp-ribosylation, enzyme, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55749.41 |
Authors | Sowa, S.T.,Lehtio, L. (deposition date: 2019-11-28, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Waaler, J.,Leenders, R.G.G.,Sowa, S.T.,Alam Brinch, S.,Lycke, M.,Nieczypor, P.,Aertssen, S.,Murthy, S.,Galera-Prat, A.,Damen, E.,Wegert, A.,Nazare, M.,Lehtio, L.,Krauss, S. Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. J.Med.Chem., 63:6834-6846, 2020 Cited by PubMed: 32511917DOI: 10.1021/acs.jmedchem.0c00208 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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