6TJ8
Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine diphosphate
Summary for 6TJ8
Entry DOI | 10.2210/pdb6tj8/pdb |
Descriptor | Transketolase 1, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 149254.04 |
Authors | Rabe von Pappenheim, F.,Tittmann, K. (deposition date: 2019-11-25, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Rabe von Pappenheim, F.,Aldeghi, M.,Shome, B.,Begley, T.,de Groot, B.L.,Tittmann, K. Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine. Nat.Chem.Biol., 16:1237-1245, 2020 Cited by PubMed: 32839604DOI: 10.1038/s41589-020-0628-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.921 Å) |
Structure validation
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