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6TJ8

Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine diphosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004802molecular_functiontransketolase activity
A0005829cellular_componentcytosol
A0006098biological_processpentose-phosphate shunt
A0009052biological_processpentose-phosphate shunt, non-oxidative branch
A0016740molecular_functiontransferase activity
A0016744molecular_functiontransketolase or transaldolase activity
A0030145molecular_functionmanganese ion binding
A0030976molecular_functionthiamine pyrophosphate binding
A0042803molecular_functionprotein homodimerization activity
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0003824molecular_functioncatalytic activity
B0004802molecular_functiontransketolase activity
B0005829cellular_componentcytosol
B0006098biological_processpentose-phosphate shunt
B0009052biological_processpentose-phosphate shunt, non-oxidative branch
B0016740molecular_functiontransferase activity
B0016744molecular_functiontransketolase or transaldolase activity
B0030145molecular_functionmanganese ion binding
B0030976molecular_functionthiamine pyrophosphate binding
B0042803molecular_functionprotein homodimerization activity
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues26
Detailsbinding site for residue NDQ A 701
ChainResidue
AALA29
AASN185
AILE187
AILE189
AILE247
AHIS261
ACA702
AEDO714
AHOH807
AHOH815
AHOH877
AHIS66
AHOH948
AHOH1169
BASP381
BGLU411
BPHE437
BTYR440
BHIS473
AGLY114
APRO115
ALEU116
AGLY154
AASP155
AGLY156
AGLU160

site_idAC2
Number of Residues5
Detailsbinding site for residue CA A 702
ChainResidue
AASP155
AASN185
AILE187
ANDQ701
AHOH948

site_idAC3
Number of Residues6
Detailsbinding site for residue EDO A 703
ChainResidue
APHE375
ATRP390
ASER393
AASN403
ATYR404
ATYR430

site_idAC4
Number of Residues6
Detailsbinding site for residue EDO A 704
ChainResidue
ASER559
AGLU560
APHE645
AHOH840
AHOH1236
AHOH1273

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 705
ChainResidue
ALEU45
ALYS46
AHIS47
ALYS303
AHOH1073

site_idAC6
Number of Residues7
Detailsbinding site for residue EDO A 706
ChainResidue
AILE615
AASP617
ATHR633
AHOH1345
AHOH1375
BARG483
BHOH839

site_idAC7
Number of Residues9
Detailsbinding site for residue EDO A 707
ChainResidue
ALEU435
AASP462
APRO475
AVAL479
AARG492
AGLU612
AALA613
AGLY614
AHOH1079

site_idAC8
Number of Residues10
Detailsbinding site for residue EDO A 708
ChainResidue
AHIS47
AARG57
AASP58
APHE60
ATYR80
AGLY108
AGLU110
AHOH825
AHOH839
AHOH1072

site_idAC9
Number of Residues3
Detailsbinding site for residue EDO A 709
ChainResidue
ATHR326
AHOH963
AHOH1175

site_idAD1
Number of Residues5
Detailsbinding site for residue EDO A 710
ChainResidue
AHOH812
AHOH1322
AHOH1361
BASP399
BHOH988

site_idAD2
Number of Residues7
Detailsbinding site for residue EDO A 711
ChainResidue
AARG4
AARG42
AGLN293
AHOH915
AHOH995
BGLY392
BLYS394

site_idAD3
Number of Residues6
Detailsbinding site for residue EDO A 712
ChainResidue
ATYR620
AGLY624
ALEU625
AASN626
AGLY627
AHOH816

site_idAD4
Number of Residues6
Detailsbinding site for residue EDO A 713
ChainResidue
AHOH1038
AHOH1140
ALYS131
ATHR172
ALYS174
AASN397

site_idAD5
Number of Residues10
Detailsbinding site for residue EDO A 714
ChainResidue
AHIS26
AILE189
AHIS261
ANDQ701
AHOH807
AHOH1318
BPHE434
BASP469
BHIS473
BHOH821

site_idAD6
Number of Residues6
Detailsbinding site for residue EDO A 715
ChainResidue
AGLN526
AGLU527
ALYS544
AVAL565
AHOH931
AHOH1305

site_idAD7
Number of Residues9
Detailsbinding site for residue EDO A 716
ChainResidue
ATYR182
AASP184
APHE197
ATHR198
AASP199
ATHR201
AHOH917
AHOH1054
AHOH1460

site_idAD8
Number of Residues8
Detailsbinding site for residue EDO A 717
ChainResidue
APHE434
AHIS461
ALEU466
AASP469
AHIS473
AARG520
BEDO711
BHOH894

site_idAD9
Number of Residues7
Detailsbinding site for residue EDO A 718
ChainResidue
AGLN136
APHE137
AARG139
AHOH833
AHOH855
AHOH955
AHOH1104

site_idAE1
Number of Residues27
Detailsbinding site for residue NDQ B 701
ChainResidue
AASP381
AGLU411
APHE437
ATYR440
AHIS473
AHOH1245
BALA29
BHIS66
BGLY114
BPRO115
BLEU116
BGLY154
BASP155
BGLY156
BGLU160
BASN185
BILE187
BILE189
BILE247
BHIS261
BCA702
BEDO711
BHOH816
BHOH874
BHOH935
BHOH1125
BHOH1207

site_idAE2
Number of Residues5
Detailsbinding site for residue CA B 702
ChainResidue
BASP155
BASN185
BILE187
BNDQ701
BHOH935

site_idAE3
Number of Residues7
Detailsbinding site for residue EDO B 703
ChainResidue
BPHE375
BTRP390
BSER393
BASN403
BTYR404
BTYR430
BHOH1163

site_idAE4
Number of Residues7
Detailsbinding site for residue EDO B 704
ChainResidue
BALA271
BTYR505
BGLU508
BARG509
BEDO714
BHOH891
BHOH970

site_idAE5
Number of Residues9
Detailsbinding site for residue EDO B 705
ChainResidue
BARG274
BGLU275
BTRP279
BARG538
BGLN592
BEDO714
BHOH893
BHOH985
BHOH1072

site_idAE6
Number of Residues5
Detailsbinding site for residue EDO B 706
ChainResidue
BLEU272
BGLU275
BARG509
BASP511
BHOH1078

site_idAE7
Number of Residues6
Detailsbinding site for residue EDO B 707
ChainResidue
BLYS21
BLYS88
BGLN92
BHOH852
BHOH865
BHOH932

site_idAE8
Number of Residues6
Detailsbinding site for residue EDO B 708
ChainResidue
BGLU6
BGLY278
BTRP279
BLYS280
BTYR281
BHOH1101

site_idAE9
Number of Residues9
Detailsbinding site for residue EDO B 709
ChainResidue
BLEU435
BASP462
BPRO475
BVAL479
BARG492
BGLU612
BALA613
BGLY614
BHOH1077

site_idAF1
Number of Residues6
Detailsbinding site for residue EDO B 710
ChainResidue
BSER559
BGLU560
BPHE645
BPHE650
BHOH845
BHOH1073

site_idAF2
Number of Residues11
Detailsbinding site for residue EDO B 711
ChainResidue
AASP469
AEDO717
AHOH821
AHOH1245
BHIS26
BILE189
BHIS261
BNDQ701
BEDO718
BHOH823
BHOH1283

site_idAF3
Number of Residues3
Detailsbinding site for residue EDO B 712
ChainResidue
BTHR326
BHOH983
BHOH1440

site_idAF4
Number of Residues9
Detailsbinding site for residue EDO B 713
ChainResidue
BTYR182
BASP184
BPHE197
BTHR198
BASP199
BTHR201
BHOH801
BHOH951
BHOH1160

site_idAF5
Number of Residues7
Detailsbinding site for residue EDO B 714
ChainResidue
BALA271
BGLU275
BEDO704
BEDO705
BHOH990
BHOH1114
BHOH1355

site_idAF6
Number of Residues6
Detailsbinding site for residue EDO B 715
ChainResidue
BLYS131
BTHR172
BLYS174
BHOH987
BHOH1018
BHOH1062

site_idAF7
Number of Residues11
Detailsbinding site for residue EDO B 716
ChainResidue
BLEU45
BHIS47
BARG57
BASP58
BPHE60
BTYR80
BGLY108
BGLU110
BHOH810
BHOH826
BHOH1028

site_idAF8
Number of Residues6
Detailsbinding site for residue EDO B 717
ChainResidue
BILE246
BPHE249
BGLY250
BALA255
BGLN276
BHOH940

site_idAF9
Number of Residues10
Detailsbinding site for residue EDO B 718
ChainResidue
AASP469
BSER24
BGLY25
BHIS26
BARG91
BGLY262
BEDO711
BHOH823
BHOH894
BHOH1133

site_idAG1
Number of Residues9
Detailsbinding site for residue EDO B 719
ChainResidue
APHE635
BALA449
BLEU450
BLYS452
BASN487
BHOH848
BHOH1015
BHOH1094
BHOH1332

Functional Information from PROSITE/UniProt
site_idPS00801
Number of Residues21
DetailsTRANSKETOLASE_1 Transketolase signature 1. RalsMDavqkakSGHPGapMG
ChainResidueDetails
AARG12-GLY32

site_idPS00802
Number of Residues17
DetailsTRANSKETOLASE_2 Transketolase signature 2. GEDGPTHqPVEqvAslR
ChainResidueDetails
AGLY467-ARG483

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AGLU411
BGLU411

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:17914867
ChainResidueDetails
ASER385
AHIS461
AASP469
AHIS473
AARG520
BHIS26
BARG358
BSER385
BHIS461
BASP469
BHIS473
BARG520
AARG358
AHIS26

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:17914867, ECO:0000269|Ref.9, ECO:0007744|PDB:1QGD, ECO:0007744|PDB:2R5N
ChainResidueDetails
BHIS66
BGLY114
BASN185
BHIS261
AASN185
AHIS261
AHIS66
AGLY114

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:17914867, ECO:0000305|Ref.9
ChainResidueDetails
BASP155
BILE187
AILE187
AASP155

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|Ref.9, ECO:0007744|PDB:1QGD
ChainResidueDetails
AGLY156
BGLY156

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:17914867, ECO:0000269|Ref.9
ChainResidueDetails
APHE437
BPHE437

site_idSWS_FT_FI7
Number of Residues4
DetailsSITE: Important for catalytic activity
ChainResidueDetails
BHIS26
BHIS261
AHIS261
AHIS26

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842
ChainResidueDetails
ALYS46
BLYS46

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PDB entries from 2024-06-12

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