6TGW
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor
Summary for 6TGW
Entry DOI | 10.2210/pdb6tgw/pdb |
Related | 5FHZ |
Descriptor | Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate, ... (4 entities in total) |
Functional Keywords | aldh1a3, aldehyde dehydrogenase aldh inhibitor cancer stem cell, glioblastoma mesenchymal stem cell stem cell, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 228856.30 |
Authors | Garavaglia, S.,Rizzi, M. (deposition date: 2019-11-18, release date: 2021-06-02, Last modification date: 2024-01-24) |
Primary citation | Li, J.,Garavaglia, S.,Ye, Z.,Moretti, A.,Belyaeva, O.V.,Beiser, A.,Ibrahim, M.,Wilk, A.,McClellan, S.,Klyuyeva, A.V.,Goggans, K.R.,Kedishvili, N.Y.,Salter, E.A.,Wierzbicki, A.,Migaud, M.E.,Mullett, S.J.,Yates, N.A.,Camacho, C.J.,Rizzi, M.,Sobol, R.W. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Commun Biol, 4:1420-1420, 2021 Cited by PubMed: 34934174DOI: 10.1038/s42003-021-02949-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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