6TCY
X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS555
This is a non-PDB format compatible entry.
Summary for 6TCY
Entry DOI | 10.2210/pdb6tcy/pdb |
Descriptor | Histone deacetylase 6, DIMETHYL SULFOXIDE, ZINC ION, ... (11 entities in total) |
Functional Keywords | protein deacetylase, histone deacetylase 6, zinc-binding, isoxazole-2 3-hydroxamate analogues, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81738.80 |
Authors | Stransky, J.,Barinka, C. (deposition date: 2019-11-06, release date: 2020-11-04, Last modification date: 2024-01-24) |
Primary citation | Noonepalle, S.,Shen, S.,Ptacek, J.,Tavares, M.T.,Zhang, G.,Stransky, J.,Pavlicek, J.,Ferreira, G.M.,Hadley, M.,Pelaez, G.,Barinka, C.,Kozikowski, A.P.,Villagra, A. Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. J.Med.Chem., 63:10246-10262, 2020 Cited by PubMed: 32815366DOI: 10.1021/acs.jmedchem.0c00567 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report