6TCX

Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis

This is a non-PDB format compatible entry.

Summary for 6TCX

• Entry DOI: 10.2210/pdb6tcx/pdb
• Descriptor: Papain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (2~{R})-2-[[(1~{S})-1-[(6~{S})-2-azanyl-1,4,5,6-tetrahydropyrimidin-6-yl]-2-[[(2~{S})-3-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]amino]-2-oxidanylidene-ethyl]carbamoylamino]-3-(4-hydroxyphenyl)propanoic acid, ... (4 entities in total)
• Functional Keywords: peptide inhibitor, cysteine protease, papain, structural genomics consortium, sgc, hydrolase
• Biological source: Carica papaya (Papaya)
• Total number of polymer chains: 1
• Total formula weight: 24302.29

Authors

Kraemer, A.,Juettner, N.E.,Fuchsbauer, H.-L.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-11-06, release date: 2019-12-04, Last modification date: 2024-01-24)

• Primary citation: Juettner, N.E.,Bogen, J.P.,Bauer, T.A.,Knapp, S.,Pfeifer, F.,Huettenhain, S.H.,Meusinger, R.,Kraemer, A.,Fuchsbauer, H.L.; Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.; J.Nat.Prod., 83:2983-2995, 2020; PubMed: 32998509; DOI: 10.1021/acs.jnatprod.0c00201

Experimental method

X-RAY DIFFRACTION (1.65 Å)