6TCX
Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis
This is a non-PDB format compatible entry.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWAfSA |
| Chain | Residue | Details |
| AAA | GLN19-ALA30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VDHAVAAVGYG |
| Chain | Residue | Details |
| AAA | VAL157-GLY167 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YILiKNSWgtgWGenGYIrI |
| Chain | Residue | Details |
| AAA | TYR170-ILE189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000269|PubMed:5681232, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0000305|PubMed:1860874, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP |
| Chain | Residue | Details |
| AAA | CYS25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP |
| Chain | Residue | Details |
| AAA | HIS159 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090, ECO:0000269|PubMed:5681232, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP |
| Chain | Residue | Details |
| AAA | ASN175 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: covalent => ECO:0000269|PubMed:8416808, ECO:0007744|PDB:1POP |
| Chain | Residue | Details |
| AAA | CYS25 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 174 |
| Chain | Residue | Details |
| AAA | GLN19 | electrostatic stabiliser, hydrogen bond donor |
| AAA | CYS25 | electrostatic stabiliser |
| AAA | HIS159 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| AAA | ASN175 | activator, electrostatic stabiliser, hydrogen bond acceptor |
