6T97
Trypanothione Reductase from Leismania infantum in complex with TRL190
Summary for 6T97
Entry DOI | 10.2210/pdb6t97/pdb |
Related | 6T95 |
Descriptor | Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, oxidoreductase, leishmania, drug, flavoprotein |
Biological source | Leishmania infantum |
Total number of polymer chains | 1 |
Total formula weight | 54945.80 |
Authors | Carriles, A.,Hermoso, J.A. (deposition date: 2019-10-26, release date: 2020-11-18, Last modification date: 2024-01-24) |
Primary citation | Revuelto, A.,de Lucio, H.,Carriles, A.,Garcia Soriano, J.C.,Sanchez-Murcia, P.A.,Hermoso, J.A.,Gago, F.,Camarasa, M.J.,Jimenez-Ruiz, A.,Velazquez, S. Scaffold hopping identifies new triazole-and triazolium-based inhibitors of Leishmania infantum Trypanothione Reductase with potent and selective antileishmanial activity To Be Published, |
Experimental method |
Structure validation
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