6T97
Trypanothione Reductase from Leismania infantum in complex with TRL190
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | GLY11 |
| A | THR51 |
| A | CYS52 |
| A | GLY56 |
| A | CYS57 |
| A | LYS60 |
| A | GLY127 |
| A | ALA159 |
| A | THR160 |
| A | GLY161 |
| A | TYR198 |
| A | GLY13 |
| A | ARG287 |
| A | ARG290 |
| A | LEU294 |
| A | GLY326 |
| A | ASP327 |
| A | MET333 |
| A | LEU334 |
| A | THR335 |
| A | PRO336 |
| A | HIS461 |
| A | SER14 |
| A | PRO462 |
| A | HOH624 |
| A | HOH628 |
| A | HOH637 |
| A | GLY15 |
| A | VAL34 |
| A | ASP35 |
| A | ALA46 |
| A | ALA47 |
| A | GLY50 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ARG3 |
| A | LYS240 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | TYR221 |
| A | ARG222 |
| A | ARG228 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | GLN37 |
| A | ALA38 |
| A | THR39 |
| A | MET124 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | HIS40 |
| A | ASN100 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | ARG228 |
| A | ARG235 |
| A | HOH671 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | SER470 |
| A | ARG472 |
| A | THR473 |
| A | HOH620 |
| A | HOH678 |
| A | HOH679 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | GLN68 |
| A | PRO371 |
| A | SER433 |
| A | PRO435 |
| A | GLU436 |
| A | HOH614 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | ASN421 |
| A | HOH641 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue MWW A 510 |
| Chain | Residue |
| A | GLU18 |
| A | TRP21 |
| A | SER105 |
| A | SER109 |
| A | TYR110 |
| A | MET113 |
| A | ASP116 |
| A | THR117 |
| A | GLU118 |
| A | LEU399 |
| A | HOH613 |
| A | HOH692 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY49-PRO59 |
