6T7H
Crystal structure of Thrombin in complex with macrocycle N14-PR4-A
Summary for 6T7H
Entry DOI | 10.2210/pdb6t7h/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | serine protease, blood clotting factor, inhibition, macrocycle, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 69673.58 |
Authors | Angelini, A.,Kumar, M.G.,Heinis, C.,Cendron, L. (deposition date: 2019-10-22, release date: 2020-09-30, Last modification date: 2024-01-24) |
Primary citation | Mothukuri, G.K.,Kale, S.S.,Stenbratt, C.L.,Zorzi, A.,Vesin, J.,Bortoli Chapalay, J.,Deyle, K.,Turcatti, G.,Cendron, L.,Angelini, A.,Heinis, C. Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries. Chem Sci, 11:7858-7863, 2020 Cited by PubMed: 34094158DOI: 10.1039/d0sc01944e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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