6T4W

ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand Glenmark

Summary for 6T4W

Entry DOI	10.2210/pdb6t4w/pdb
Descriptor	Nuclear receptor ROR-gamma, GLYCEROL, 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, ... (5 entities in total)
Functional Keywords	nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29089.65
Authors	de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2019-10-15, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L. Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33536342 DOI: 10.1073/pnas.2021287118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation