6T3J

Dual Epitope Targeting by Anti-DR5 Antibodies

Summary for 6T3J

• Entry DOI: 10.2210/pdb6t3j/pdb
• Descriptor: IgG1-hDR5-01-Heavy Chain, IgG1-hDR5-01-Light Chain, IgG1-hDR5-05-Heavy Chain, ... (5 entities in total)
• Functional Keywords: dr5, antibody, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 223384.30

Authors

Tauchert, M.J.,Augustin, M.,Krapp, S.,Overdijk, M.B.,Breij, E.C.W.,Hibbert, R.G. (deposition date: 2019-10-11, release date: 2020-09-16, Last modification date: 2020-10-14)

• Primary citation: Overdijk, M.B.,Strumane, K.,Beurskens, F.J.,Ortiz Buijsse, A.,Vermot-Desroches, C.,Vuillermoz, B.S.,Kroes, T.,de Jong, B.,Hoevenaars, N.,Hibbert, R.G.,Lingnau, A.,Forssmann, U.,Schuurman, J.,Parren, P.W.H.I.,de Jong, R.N.,Breij, E.C.W.; Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.; Mol.Cancer Ther., 19:2126-2138, 2020; PubMed: 32847982; DOI: 10.1158/1535-7163.MCT-20-0044

Experimental method

X-RAY DIFFRACTION (3.05 Å)