6T28
Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 19 (CS640)
This is a non-PDB format compatible entry.
Summary for 6T28
Entry DOI | 10.2210/pdb6t28/pdb |
Descriptor | Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, kinase, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43844.71 |
Authors | Kraemer, A.,Sorrell, F.,Butterworth, S.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-08, release date: 2019-11-13, Last modification date: 2024-01-24) |
Primary citation | Fromont, C.,Atzori, A.,Kaur, D.,Hashmi, L.,Greco, G.,Cabanillas, A.,Nguyen, H.V.,Jones, D.H.,Garzon, M.,Varela, A.,Stevenson, B.,Iacobini, G.P.,Lenoir, M.,Rajesh, S.,Box, C.,Kumar, J.,Grant, P.,Novitskaya, V.,Morgan, J.,Sorrell, F.J.,Redondo, C.,Kramer, A.,Harris, C.J.,Leighton, B.,Vickers, S.P.,Cheetham, S.C.,Kenyon, C.,Grabowska, A.M.,Overduin, M.,Berditchevski, F.,Weston, C.J.,Knapp, S.,Fischer, P.M.,Butterworth, S. Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesityin VivoMouse Model. J.Med.Chem., 63:6784-6801, 2020 Cited by PubMed: 32433887DOI: 10.1021/acs.jmedchem.9b01803 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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