6T1N
Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 5
Summary for 6T1N
Entry DOI | 10.2210/pdb6t1n/pdb |
Descriptor | Protein ENL, 4-chloranyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription, yeats domain, enl, mllt1, chemical probe, inhibitor, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19028.34 |
Authors | Chaikuad, A.,Heidenreich, D.,Moustakim, M.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fedorov, O.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-04, release date: 2019-11-06, Last modification date: 2024-01-24) |
Primary citation | Ni, X.,Heidenreich, D.,Christott, T.,Bennett, J.,Moustakim, M.,Brennan, P.E.,Fedorov, O.,Knapp, S.,Chaikuad, A. Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10:1661-1666, 2019 Cited by PubMed: 31857843DOI: 10.1021/acsmedchemlett.9b00460 PDB entries with the same primary citation |
Experimental method |
Structure validation
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