6T1L
Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 3
Summary for 6T1L
Entry DOI | 10.2210/pdb6t1l/pdb |
Descriptor | Protein ENL, 1,2-ETHANEDIOL, ~{N}-[[4-(diethylaminomethyl)phenyl]methyl]-4-pyrimidin-2-yl-piperazine-1-carboxamide, ... (4 entities in total) |
Functional Keywords | transcription, yeats domain, enl, mllt1, chemical probe, inhibitor, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19228.19 |
Authors | Chaikuad, A.,Heidenreich, D.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fedorov, O.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-04, release date: 2019-11-06, Last modification date: 2024-01-24) |
Primary citation | Ni, X.,Heidenreich, D.,Christott, T.,Bennett, J.,Moustakim, M.,Brennan, P.E.,Fedorov, O.,Knapp, S.,Chaikuad, A. Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1. Acs Med.Chem.Lett., 10:1661-1666, 2019 Cited by PubMed: 31857843DOI: 10.1021/acsmedchemlett.9b00460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report