6SQU
Crystal structure of human SHIP2 catalytic domain in complex with 1,2,4 Dimer
Summary for 6SQU
Entry DOI | 10.2210/pdb6squ/pdb |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 5,5'-(ethane-1,2-diylbis(oxy))bis(benzene-5,4,2,1,-tetrayl)hexakisphosphate (3 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73277.84 |
Authors | Whitfield, H.,Brearley, C.A.,Hemmings, A.M. (deposition date: 2019-09-04, release date: 2021-01-13, Last modification date: 2024-01-24) |
Primary citation | Whitfield, H.,Hemmings, A.M.,Mills, S.J.,Baker, K.,White, G.,Rushworth, S.,Riley, A.M.,Potter, B.V.L.,Brearley, C.A. Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention. J.Med.Chem., 64:3813-3826, 2021 Cited by PubMed: 33724834DOI: 10.1021/acs.jmedchem.0c01944 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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