6SKH
X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor sulfamide inhibitor GluAsp
Summary for 6SKH
Entry DOI | 10.2210/pdb6skh/pdb |
Descriptor | Glutamate carboxypeptidase 2, CHLORIDE ION, beta-D-mannopyranose, ... (15 entities in total) |
Functional Keywords | glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; sulfamide, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 84329.36 |
Authors | Motlova, L.,Novakova, Z.,Barinka, C. (deposition date: 2019-08-15, release date: 2020-08-26, Last modification date: 2024-01-31) |
Primary citation | Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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