6SIS
Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB
Summary for 6SIS
Entry DOI | 10.2210/pdb6sis/pdb |
Descriptor | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... (6 entities in total) |
Functional Keywords | protac complex, macrocycle, targeted degradation, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 115212.83 |
Authors | Hughes, S.J.,Testa, A.,Ciulli, A. (deposition date: 2019-08-10, release date: 2019-12-04, Last modification date: 2024-01-24) |
Primary citation | Testa, A.,Hughes, S.J.,Lucas, X.,Wright, J.E.,Ciulli, A. Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59:1727-1734, 2020 Cited by PubMed: 31746102DOI: 10.1002/anie.201914396 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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