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6SIS

Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB

Summary for 6SIS
Entry DOI10.2210/pdb6sis/pdb
DescriptorBromodomain-containing protein 4, Elongin-B, Elongin-C, ... (6 entities in total)
Functional Keywordsprotac complex, macrocycle, targeted degradation, ligase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight115212.83
Authors
Hughes, S.J.,Testa, A.,Ciulli, A. (deposition date: 2019-08-10, release date: 2019-12-04, Last modification date: 2024-01-24)
Primary citationTesta, A.,Hughes, S.J.,Lucas, X.,Wright, J.E.,Ciulli, A.
Structure-Based Design of a Macrocyclic PROTAC.
Angew.Chem.Int.Ed.Engl., 59:1727-1734, 2020
Cited by
PubMed: 31746102
DOI: 10.1002/anie.201914396
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

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