6SIS

Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0030891	cellular_component	VCB complex
B	0070449	cellular_component	elongin complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0030891	cellular_component	VCB complex
F	0070449	cellular_component	elongin complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue LFE D 301

Chain	Residue
A	TRP374
A	VAL439
D	TRP88
D	TYR98
D	PRO99
D	ARG107
D	HIS110
D	SER111
D	TYR112
D	HIS115
A	PRO375
A	ALA384
A	LEU385
A	GLY386
A	LEU387
A	ASN433
A	HIS437
A	GLU438

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site_id	AC2
Number of Residues	18
Details	binding site for residue LFE H 301

Chain	Residue
E	TRP374
E	PRO375
E	ALA384
E	LEU385
E	LEU387
E	ASN433
E	HIS437
E	GLU438
E	VAL439
H	TRP88
H	TYR98
H	PRO99
H	ARG107
H	ILE109
H	HIS110
H	SER111
H	TYR112
H	HIS115

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1
F	MET1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
B	THR84
F	THR84

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