6SGP
X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu
Summary for 6SGP
Entry DOI | 10.2210/pdb6sgp/pdb |
Descriptor | Glutamate carboxypeptidase 2, DI(HYDROXYETHYL)ETHER, (2~{S})-2-[[(2~{S})-1,5-bis(oxidanyl)-1,5-bis(oxidanylidene)pentan-2-yl]sulfamoylamino]pentanedioic acid, ... (13 entities in total) |
Functional Keywords | glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen;sulfamide, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 84143.20 |
Authors | Barinka, C.,Shukla, S.,Motlova, L. (deposition date: 2019-08-05, release date: 2020-08-26, Last modification date: 2024-01-31) |
Primary citation | Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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