6SC9

dAb3/HOIP-RBR-HOIPIN-8

Summary for 6SC9

Entry DOI	10.2210/pdb6sc9/pdb
Descriptor	E3 ubiquitin-protein ligase RNF31, Single domain antibody, 2-[3-[2,6-bis(fluoranyl)-4-(1~{H}-pyrazol-4-yl)phenyl]-3-oxidanylidene-prop-1-enyl]-4-(1-methylpyrazol-4-yl)benzoic acid, ... (7 entities in total)
Functional Keywords	human single domain antibody, hoip, rbr, inhibitor, immune system, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	70614.23
Authors	Tsai, Y.-C.I.,Johansson, H.,House, D.,Rittinger, K. (deposition date: 2019-07-23, release date: 2019-11-27, Last modification date: 2024-05-01)
Primary citation	Tsai, Y.I.,Johansson, H.,Dixon, D.,Martin, S.,Chung, C.W.,Clarkson, J.,House, D.,Rittinger, K. Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases. Cell Chem Biol, 27:83-, 2020 Cited by PubMed: 31813847 DOI: 10.1016/j.chembiol.2019.11.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation