6SB0
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
Summary for 6SB0
Entry DOI | 10.2210/pdb6sb0/pdb |
EMDB information | 10132 |
Descriptor | mTOR,Serine/threonine-protein kinase mTOR,mTOR,Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Ras-related GTP-binding protein A, ... (8 entities in total) |
Functional Keywords | small gtpases, mtorc1 activator, roadblock domain, gtpase domain, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 1162771.68 |
Authors | Anandapadamanaban, M.,Berndt, A.,Masson, G.R.,Perisic, O.,Williams, R.L. (deposition date: 2019-07-18, release date: 2019-10-16, Last modification date: 2024-05-22) |
Primary citation | Anandapadamanaban, M.,Masson, G.R.,Perisic, O.,Berndt, A.,Kaufman, J.,Johnson, C.M.,Santhanam, B.,Rogala, K.B.,Sabatini, D.M.,Williams, R.L. Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366:203-210, 2019 Cited by PubMed: 31601764DOI: 10.1126/science.aax3939 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (5.5 Å) |
Structure validation
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