6S5Q
Strictosidine Synthase from Ophiorrhiza pumila in complex with (S)-1-isobutyl-2,3,4,9-tetrahydro-1H-beta-carboline
Summary for 6S5Q
Entry DOI | 10.2210/pdb6s5q/pdb |
Descriptor | Strictosidine synthase, (1~{S})-1-(2-methylpropyl)-2,3,4,9-tetrahydro-1~{H}-pyrido[3,4-b]indole (3 entities in total) |
Functional Keywords | alkaloid, c-c bond, pictet-spenglerase, lyase |
Biological source | Ophiorrhiza pumila |
Total number of polymer chains | 1 |
Total formula weight | 36998.24 |
Authors | Eger, E.,Sharma, M.,Kroutil, W.,Grogan, G. (deposition date: 2019-07-02, release date: 2020-04-08, Last modification date: 2024-01-24) |
Primary citation | Eger, E.,Simon, A.,Sharma, M.,Yang, S.,Breukelaar, W.B.,Grogan, G.,Houk, K.N.,Kroutil, W. Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet-Spengler Reactions. J.Am.Chem.Soc., 142:792-800, 2020 Cited by PubMed: 31909617DOI: 10.1021/jacs.9b08704 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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